4-Isothiocyanato-2-(Trifluoromethyl)benzonitrile CAS 143782-23-4 Enzalutamide Intermediate Purity >98.0% (GC)
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 4-Isothiocyanato-2-(Trifluoromethyl)benzonitrile (CAS: 143782-23-4) with high quality, intermediate of Enzalutamide (CAS: 915087-33-1). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Enzalutamide Intermediates, Please contact: alvin@ruifuchem.com
| Chemical Name | 4-Isothiocyanato-2-(Trifluoromethyl)benzonitrile |
| Synonyms | 4-Cyano-3-(Trifluoromethyl)phenyl Isothiocyanate; Isothiocyanic Acid 4-Cyano-3-(Trifluoromethyl)phenyl Ester; 4-Isothiocyanato-2-Trifluoromethylbenzonitrile; 3-Fluoro-4-Methylphenylisothiocyanate |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 143782-23-4 |
| Molecular Formula | C9H3F3N2S |
| Molecular Weight | 228.19 g/mol |
| Melting Point | 39.0 to 43.0℃ |
| Boiling Point | 331℃ |
| Flash Point | 154℃ |
| Density | 1.31 |
| Sensitive | Moisture Sensitive, Heat Sensitive |
| COA & MSDS | Available |
| Sample | Available |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | Off-White Powder | Off-White Powder |
| Melting Point | 39.0 to 43.0℃ | 41.2℃ |
| Loss on Drying | <0.50% | 0.19% |
| Purity / Analysis Method | >98.0% (HPLC) | 98.8% |
| Infrared Spectrum | Consistent with Structure | Complies |
| 1H NMR Spectrum | Consistent with Structure | Complies |
| Conclusion | The product has been tested and complies with the given specifications | |
| Application | Intermediate of Enzalutamide (CAS: 915087-33-1) | |
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
H302 + H312 + H332: Harmful if swallowed, in contact with skin or if inhaled.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
P501: Dispose of contents/ container to an approved waste disposal plant.
P261: Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/ protective clothing/ eye protection/ face protection.
P337 + P313: If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P362: Take off contaminated clothing and wash before reuse.
P301 + P312 + P330: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P302 + P352 + P312: IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P312: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
4-Isothiocyanato-2-(Trifluoromethyl)benzonitrile (CAS: 143782-23-4) is used as an intermediate of Enzalutamide (CAS: 915087-33-1). Enzalutamide (XTANDI) is an oral androgen receptor antagonist, which is approved by the current clinical research and the US FDA (Food and Drug Administration), for the development of post-chemotherapy metastatic castration tolerance of prostate cancer Treatment (i.e. patients with prostate cancer after chemotherapy, cancer or cancer cells are still growing in such patients), can extend the survival of patients. In August 2012, the US FDA approved enzalutamide for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in patients who have previously been treated with Docetaxel.
Enzalutamide is approved to treat: 1. Prostate cancer. It is used: 1.1. In patients whose cancer is castration resistant (has not responded to treatments that lower testosteroneslevels). 1.2. In patients whose cancer has metastasizedand is castration sensitive (has responded to treatments that lower testosterones levels). Enzalutamide is also being studied in the treatment of other types of cancer.
